Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant omicron variant. Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity vaccine immunogenicity. variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concernArticle Published on 2022-10-032022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] BNT162b2 booster breadth Breakthrough infection Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine ENhance extended interval generate identify immune response immune responses immunogen individual Lineage magnitude memory B cells Mutation neutralization activity neutralization breadth Neutralizing antibody response of BNT162b2 omicron Population proportion reactive receiving regimen SARS-CoV-2 variant second dose spike Surface glycoprotein two groups vaccination Vaccination strategy Vaccine vaccine dose [DOI] 10.1371/journal.ppat.1010882 PMC 바로가기
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variantsArticle Published on 2022-09-262022-11-15 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding Affinity maturation analysis Analysis antibody Antibody Response Antigen antigens caused cleavage site Combination coronavirus coronavirus determine Evolution fusion peptide immunization immunogen Infection Mutation outbreak predict promote PROTECT RBD expression SARS-CoV-2 variant sequence spike Strains Structure targets the antibody response Vaccine variant variants virus wildtype zoonotic coronavirus [DOI] 10.1371/journal.pcbi.1010563 PMC 바로가기
Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody responseArticle Published on 2022-09-162022-11-15 Journal: Science Advances [Category] SARS, 변종, 진단, [키워드] amino acid change change Characteristics conserved COVID distribution elicit ENhance immune response immunogen immunogens IMPROVE in vitro Mutation neutralizing antibody Neutralizing antibody response neutralizing epitopes nine platform RBD Receptor binding domain sequence Spike protein the SARS-CoV-2 Vaccine vaccine antigen vaccine platform Vaccines variants of concern [DOI] 10.1126/sciadv.abq8276 PMC 바로가기
A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorArticle Published on 2022-09-132022-11-15 Journal: Cell Reports [Category] SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 antibodies antibody antibody repertoire Bioactivity characterized contribute CP: Immunology deep sequencing developmental Donor early infection elicit event facilitate immunogen information Lineage longitudinal maturation monoclonal NAb neutralizing antibody neutralizing antibody. P2C-1F11 lineage pathway reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific antibody sequence significantly viral infection [DOI] 10.1016/j.celrep.2022.111335 PMC 바로가기
Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine modelArticle Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 진단, [키워드] BALB/c mice cellular change control group coronavirus dose group immunogen immunogenic immunogenicity Inflammatory inoculated mice murine model Protein Public public health RBD risk Safe SARS-CoV-2 Seroconversion shown spike spike glycoprotein subunit Surveillance the RBD vaccination. Vaccine vaccine candidate variants variants of concern virus were used [DOI] 10.1016/j.tmaid.2022.102427 PMC 바로가기